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Guangzhou Quanao Chemical Co., Ltd.

Acadesine, Aicar, Aica-Riboside manufacturer / supplier in China, offering Pharmaceutical Intermediates Acadesine CAS: 2627-69-2 Treating Cardiovascular Diseases, Tamoxifen Citrate Anabolic Steroids Powder Breast Cancer Health Anti Estrogen Steroids Supplements Cutting Agent, Oral Anobolic Steroids Male Sex Hormone Drugs Anti-Estrogen Steroids Arimidex 120511-73-1 and so on.

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Supplier Homepage Product Pharmaceutical Intermediates Pharmaceutical Intermediates Acadesine CAS: 2627-69-2 Treating Cardiovascular Diseases

Pharmaceutical Intermediates Acadesine CAS: 2627-69-2 Treating Cardiovascular Diseases

FOB Price: US $1 / gram
Min. Order: 10 gram
Min. Order FOB Price
10 gram US $1/ gram
Get Latest Price
Production Capacity: 3000kg/Month
Transport Package: Foil Bags
Payment Terms: T/T, Paypal, Money Gram, Western Union, Bitcoin

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Basic Info
  • Model NO.: CAS: 57-55-6
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: 98%
  • Acadesine-Molecular Formula: C9h14n4o5
  • Acadesine-Assay: 98%
  • Acadesine-Usage: Pharmaceutical Intermediates.
  • Lead Time: 4-7 Days
  • Shipping: EMS, DHL, UPS, TNT, FedEx
  • Specification: SGS
  • Powder: Yes
  • Certification: ISO 9001
  • State: Solid
  • Acadesine-Einecs: 220-097-5
  • Acadesine-Molecular Weight: 258.23
  • Acadesine-appearance: White or off-White Powder.
  • Delivery: Sent out Within 12 Hours After Payment Confirmed
  • Packaging: Disguised Package or as Required
  • Trademark: QA
  • Origin: Guangzhou China
Product Description
Pharmaceutical intermediates Acadesine CAS: 2627-69-2 treating cardiovascular diseases
 
Quick Detail:
Acadesine
Acadesine-Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE 
Acadesine-CAS: 2627-69-2 
Acadesine-EINECS: 220-097-5 
Acadesine-Molecular Formula: C9H14N4O5 
Acadesine-Molecular Weight: 258.23 
Acadesine-Assay: 98% 
Acadesine-Apperance: White or off-white powder. 
Acadesine-Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases
 
Pharmaceutical Intermediates Acadesine CAS: 2627-69-2 Treating Cardiovascular Diseases
Acadesine-Functions:

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the 
coactivation of PPAR&alpha. In adipocyte studies it has been shown 
to antagonize lipolysis induced by isoprenaline and has been suggested
 for use in kinase cascade research. Additionally, research indicates that
 AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the 
activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated 
derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole 
carboxamide ribonucleotide transformylase/inosine monophosphate 
cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and 
p70 S6 Kinase.

 
Acadesine-Specification:
ItemSpecificationResult
AppearanceWhite powderComplies
Related substance (HPLC)Total impurity ≤0.5%
Max single impurity ≤0.1%
0.2%
0.06%
OdorCharacteristicComplies
Assay99%99.8%
Sieve analysis100% pass 80 meshComplies
Loss on Drying
Residue on Ignition
≤1.0%
≤1.0%
0.12%
0.09%
Heavy Metal<10ppmComplies
As<0.1ppm0.05ppm
Pb<0.1ppm0.05ppm
Cd<0.1ppm0.05ppm
Residual Solvents<100ppmComplies
Residual PesticideNegativeComplies
Microbiology
 

 
Total Plate Count<1000cfu/gComplies
Yeast & Mold<100cfu/gComplies
E.ColiNegativeComplies
SalmonellaNegativeComplies
 

Description:
 
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is 
activated in times of reduced energy availability (high cellular AMP:ATP 
ratios) and serves to inhibit anabolic processes. In vivo, 
pharmacologic activation of AMPK with AICAR mimics exercise and 
triggers insulin-independent glucose uptake by skeletal muscle. 

 
Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation 
and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in 
astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-
MSCsin vitro.  

Pharmaceutical Intermediates Acadesine CAS: 2627-69-2 Treating Cardiovascular Diseases


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