Top Grade CAS 721-50-6 Local Anesthetic Drugs Low Toxicity Prilocaine
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|Min. Order:||10 gram|
|Port:||Hong Kong, Hong Kong|
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- Model NO.: 721-50-6
- Customized: Customized
- Suitable for: Elderly, Adult
- Purity: >99%
- CAS: 721-50-6
- Minimum Order Quantity: Negotiation Price:Negotiation
- Delivery Time: Within 8 Hous After Receiving Your Payment
- Shipment Method: UPS DHL FedEx TNT EMS Hkems Hongkong Post Eub Etk
- Appearance: White Crystalline Powder
- Transport Package: Discreet Ways of Packing for Customs Pass Guarante
- Origin: Guangzhou
- Powder: Yes
- Certification: GMP, ISO 9001, USP, SGS Ukas
- State: Solid
- Product Name: Prilocaine
- Assay: 99%
- Packaging Details: Discreet Ways of Packing for Customs Pass Guarante
- Payment Terms: T/T, Western Union, Moneygram, Bitcoin
- Test: Free Sample
- Trademark: Quanao
- Specification: 1kg foil bag
- HS Code: 2942000000
Disguised Product Show:
|Characters||White or almost white crystalline powder||Confirms|
|Solubility||Freely soluble in water and in alcohol||Confirms|
|Assay (HPLC)||99.0--101.0% (calculated on the dried basis)||99.6%|
|Loss on Drying||Not more than 0.3%||0.16%|
|Related substances||Not more than 1.0%||0.11%|
|Acetone||Not more than 5000ppm||conforms|
|Ethanol||Not more than 5000ppm||conforms|
|Sulphated ash||Not more than 0.15%||conforms|
|Heavy Metal||Not more than 0.001%||<0.001%|
What is Prilocaine ?
Prilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Löfgren. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA).
prilocaine topical cream is used on the skin or in the genital area to cause numbness or loss of feeling before certain medical procedures. It is used to prevent pain caused by an injection, the drawing of blood from a vein, or minor surgeries such as removing warts. This medicine contains a mixture of two topical local anesthetics. It deadens the nerve endings in the skin.
Relieving pain of normal intact skin and numbing skin to pain from injections and other medical procedures.
prilocaine cream is a local anesthetic. It works by blocking nerves from transmitting painful impulses to the brain
Prilocaine ydrochloride Injection, USP, 4% is a sterile, non pyrogenic isotonic solution that contains a local anesthetic agent and is administered parenterally by injection. See INDICATIONS AND USAGE for specific uses.
Prilocaine is a local anesthetic for the anesthesia's skin and tissues and cycles; this drug is usually provided as a topical application and comma cream; but it may also be available in injectable form and comma; should be specially trained The effect of the professional and the time management; its effect is not immediate and comma; but once a person experiences the relevant numbness, it may last for hours; during this time and the comma is important to pay attention to her health care provider's Advice so that she can avoid harming yourself and during the period;
Health care providers use propranolol to imply that they manage the place of injection or carry out certain procedures and periods of feeling; this drug is considered to be a local anesthetic because it is usually applied to the area of need and cycle; for example & comma if the dentist Use it and the comma he may inject the drug into his work area and the gingival near the periodic location;
In addition to injectable forms and commas, this drug can also be used as a cream and a period of time; cream is suitable for a particular area and period; injections and commas may take longer to take effect; its effects may be more limited and cycle; In the case of commas, once numbness begins, it may last for hours;
In some patients, metabolites of prilocaine may cause abnormal side effects of methemoglobinemia and may be treated with methylene blue.
Local anesthesia is a substance that causes sensory loss only in its application area without affecting consciousness. Most local anesthetic structures have an amino ester or aminoamide group attached to a hydrophilic (secondary or tertiary amine) and the other side of the hydrophobic group (aromatic compound).
Local anesthetics, long duration, low toxicity, chemical substances are also smaller for epidural anesthesia, block anesthesia and infiltration anesthesia.
Lidocaine and Prilocaine - Clinical Pharmacology
Mechanism of Action:
Lidocaine and Prilocaine cream, applied to intact skin under occlusive dressing, provides dermal analgesia by the release of Lidocaine and Prilocaine from the cream into the epidermal and dermal layers of the skin and by the accumulation of Lidocaine and Prilocaine in the vicinity of dermal pain receptors and nerve endings. Lidocaine and Prilocaine are amide-type local anesthetic agents. Both Lidocaine and Prilocaine stabilize neuronal membranes by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action.
The onset, depth and duration of dermal analgesia on intact skin provided by Lidocaine and Prilocaine cream, depends primarily on the duration of application. To provide sufficient analgesia for clinical procedures such as intravenous catheter placement and venipuncture, Lidocaine and Prilocaine cream, should be applied under an occlusive dressing for at least 1 hour. To provide dermal analgesia for clinical procedures such as split skin graft harvesting, Lidocaine and Prilocaine cream, should be applied under occlusive dressing for at least 2 hours. Satisfactory dermal analgesia is achieved 1 hour after application, reaches maximum at 2 to 3 hours, and persists for 1 to 2 hours after removal. Absorption from the genital mucosa is more rapid and onset time is shorter (5 to 10 minutes) than after application to intact skin. After a 5 to 10 minute application of Lidocaine and Prilocaine cream, to female genital mucosa, the average duration of effective analgesia to an argon laser stimulus (which produced a sharp, pricking pain) was 15 to 20 minutes (individual variations in the range of 5 to 45 minutes).
Dermal application of Lidocaine and Prilocaine cream, may cause a transient, local blanching followed by a transient, local redness or erythema.
Lidocaine and Prilocaine cream, is a eutectic mixture of lidocaine and prilocaine formulated as an oil in water emulsion. In this eutectic mixture, both anesthetics are liquid at room temperature (see DESCRIPTION) and the penetration and subsequent systemic absorption of both prilocaine and lidocaine are enhanced over that which would be seen if each component in crystalline form was applied separately as a topical cream.
Absorption- The amount of Lidocaine and Prilocaine systemically absorbed from Lidocaine and Prilocaine cream, is directly related to both the duration of application and to the area over which it is applied. In two pharmacokinetic studies, 60 g of Lidocaine and Prilocaine cream, (1.5 g lidocaine and 1.5 g prilocaine) was applied to 400 cm2 of intact skin on the lateral thigh and then covered by an occlusive dressing. The subjects were then randomized such that one-half of the subjects had the occlusive dressing and residual cream removed after 3 hours, while the remainder left the dressing in place for 24 hours. The results from these studies are summarized below.
Usage and Dosage
Infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours.
Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.
Epidural anesthesia: use10 to 30 mL of 1.5% ~ 1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg.
How to Use Lidocaine/ Prilocaine Cream
Use lidocaine/prilocaine cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with lidocaine/prilocaine cream. Talk to your pharmacist if you have questions about this information.
Wash and completely dry the area to be treated. Apply a thick layer of cream to the affected skin. Do not rub lidocaine/prilocaine cream into the skin.
Lidocaine/prilocaine cream should only be used on normal, unbroken skin. Do not apply to damaged skin.
Avoid getting lidocaine/prilocaine cream in your eyes, nose, or mouth. If you get lidocaine/prilocaine cream in your eyes, rinse them with plenty of water.
Wash your hands immediately after using lidocaine/prilocaine cream.
Discard unused medicine and packaging in the trash, out of the reach of children and away from pets.
If you miss a dose of lidocaine/prilocaine cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use lidocaine/prilocaine cream.
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