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Guangzhou Quanao Chemical Co., Ltd.

Benzocaine, Lidocaine Base, Tetracaine HCl manufacturer / supplier in China, offering 99% Pharmaceutical Intermediates Lidocaine / Lidocaine HCl Relieve Pain, 99% Steroids Powder Testosterones Base for Bodybuilding CAS 58-22-0 Test Base, Hot Sales Steroids Nandrolone Phenylpropionate and so on.

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Supplier Homepage Product Pharmaceutical Intermediates 99% Pharmaceutical Intermediates Lidocaine / Lidocaine HCl Relieve Pain

99% Pharmaceutical Intermediates Lidocaine / Lidocaine HCl Relieve Pain

FOB Price: US $0.7 / kg
Min. Order: 1 kg
Min. Order FOB Price
1 kg US $0.7/ kg
Get Latest Price
Port: Shenzhen, China
Production Capacity: 5000kg/Month
Payment Terms: T/T, Western Union, Paypal, Money Gram

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Basic Info
  • Model NO.: 137-58-6
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >99%
  • Manufacturer: Quanao
  • Quality Standard: USP31
  • Trademark: Huao
  • Specification: 10grams
  • HS Code: 3004409061
  • Powder: Yes
  • Certification: ISO 9001, USP, BP
  • State: Solid
  • Alias: Lidocaine Base
  • Appearance: White Crystalline Powder
  • Usage: Relieve Pain
  • Transport Package: 1kg/Aluminium Foil Bag or as Required
  • Origin: Guangzhou China
Product Description
99% Pharmaceutical Intermediates Lignocaine / Lidocaine HCL Raw Materials CAS 137-58-6 Relieve Pain

Lidocaine basic information

Product Name: Lidocaine Base 
Synonyms: 2-(Diethylamino)-N-(2, 6-dimethylphenyl)-acetamide; Lignocaine; 2-diethylaminoacet-2, 6-xylidide; Lidocaine; Xylocaine; N-(2, 6-dimethylphenyl)-N~2~, N~2~-diethylglycinamide; 2-[(2, 6-dimethylphenyl)amino]-N, N-diethyl-2-oxoethanaminium 
CAS Registry Number: 137-58-6 
Assays: 99% 
Packaging: 25kg/drum 
Molecular Formula: C14H23N2O 
Molecular Weight: 235.3447 
EINECS: 205-302-8 
Appearance: White crystal powder

Lidocaine detail description 

Lidocaine is one kind of local anesthetic drugs , like benzocaine , it was pain killer .
Many people also like benzocaine ,we concerned about how to buy and where to buy them . This is important for us to know the company you bought ,or you won't get your package . Guangzhou Quanao Chemical Co.,Ltd is one of our branch company in China ,we had specialized in this field over for 10 years, owned over 20 branches company in China, included HK .  At the same time ,we have fast and safe shipping from HK and China mainland . Let me do a trial order , you will get the best services and price .

Lidocaine hydrochloride stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.

Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. With central neural blockade these changes may be attributable to block of autonomic fibers, a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system, and/or the beta-adrenergic receptor stimulating action of epinephrine when present. The net effect is normally a modest hypotension when the recommended dosages are not exceeded.
 
Lidocaine HCL Picture 

99% Pharmaceutical Intermediates Lidocaine / Lidocaine HCl Relieve Pain

Lidocaine HCL Specification

 
Product NameLidocaine HCL
Test ItemsSpecificationTest Results
AppearanceWhite crystalline powderpass
Content Wt99.00%~101.00%99.80
IdentificationChloridate Positive
 A TEST APositive
  Melting Point 74-79ºC75.1-77.4ºC
Appearance of solution        Clear and colourlesspass
Water5.5-7.0%6.2%
Acidity PH4.0-5.55.4
Sulphated ash0.10% max0.07%
Heavy metals5ppm maxpass
2,6-dimethylaniline100ppm max pass
SulfateMeet the requirement pass


Pharmacokinetics and Metabolism

Information derived from diverse formulations, concentrations and usages reveals that Lidocaine hydrochloride is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent. Except for intravascular administration, the highest blood levels are obtained following intercostal nerve block and the lowest after subcutaneous administration.
 
The plasma binding of Lidocaine hydrochloride is dependent on drug concentration, and the fraction bound decreases with increasing concentration. At concentrations of 1 to 4 mcg of free base per mL 60 to 80 percent of Lidocaine hydrochloride is protein bound. Binding is also dependent on the plasma concentration of the alpha-1-acid glycoprotein.
 
Lidocaine hydrochloride crosses the blood-brain and placental barriers, presumably by passive diffusion.
Lidocaine hydrochloride is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of Lidocaine hydrochloride. Approximately 90% of Lidocaine hydrochloride administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. The primary metabolite in urine is a conjugate of 4-hydroxy-2,6-dimethylaniline.
 
The elimination half-life of Lidocaine hydrochloride following an intravenous bolus injection is typically 1.5 to 2 hours. Because of the rapid rate at which Lidocaine hydrochloride is metabolized, any condition that affects liver function may alter Lidocaine hydrochloride kinetics. The half-life may be prolonged two-fold or more in patients with liver dysfunction. Renal dysfunction does not affect Lidocaine hydrochloride kinetics but may increase the accumulation of metabolites.
 
Factors such as acidosis and the use of CNS stimulants and depressants affect the CNS levels of Lidocaine hydrochloride required to produce overt systemic effects. Objective adverse manifestations become increasingly apparent with increasing venous plasma levels above 6 mcg free base per mL. In the rhesus monkey arterial blood levels of 18 to 21 mcg/mL have been shown to be threshold for convulsive activity.
 
Indications and Usage for Lidocaine

Lidocaine hydrochloride injection, USP is indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed.




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99% Pharmaceutical Intermediates Lidocaine / Lidocaine HCl Relieve Pain
 
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