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Guangzhou Quanao Chemical Co., Ltd.

Sr9011, CAS: 1379686-30-2, Testosterone Phenylpropionate manufacturer / supplier in China, offering Reducing Fat Mass Chemicals Sr9011 CAS: 1379686-30-2, Calcium Pyruvate Weight Loss Steroids Enhance Exercise Endurance 52009-14-0, CAS 5949-44-0 Testosterone Steroid Hormones Testosterone Undecanoate for Muscle Bodybuilding and so on.

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Supplier Homepage Product Weight Loss Series Drugs Reducing Fat Mass Chemicals Sr9011 CAS: 1379686-30-2

Reducing Fat Mass Chemicals Sr9011 CAS: 1379686-30-2

FOB Price: US $1 / grams
Min. Order: 10 grams
Min. Order FOB Price
10 grams US $1/ grams
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Production Capacity: 5000kg/Month
Transport Package: Very Discreet or as Required
Payment Terms: T/T, Paypal, Money Gram, Western Union

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Basic Info
  • Model NO.: 1379686-30-2
  • CAS Registry Number: 1379686-30-2
  • Appearance: White Crystalline Powder
  • Specification: 10grams
  • Product Name: Sr9011
  • Assays: 98%
  • Trademark: Quanao
  • Origin: China
Product Description

SR9011
CAS: 1379686-30-2 
Molucelar Formula: C23H31ClN4O3S
Molucelar weight: 479.03524
Type:Analysis reagent
Grade Standard:Medicine Grade
Purity:99.5%(HPLC)
Apprarance:White powder.
Application: 
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic 
Standard:USP
Use:In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays.
    In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
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